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Comparative Reproductive Toxicology of Endocrine
Disruptors Program Objective: Utilize an integrated and inter-disciplinary program to investigate the comparative reproductive toxicology of endocrine disruptors on male and female reproduction using four different vertebrate species to provide insight into the mechanistic aspects of endocrine disruptor actions and extrapolate this information to human health issues. Organization: Utilizes the organization and existing structure of the Center for Reproductive Biology at Washington State University and the University of Idaho to administer and integrate the research program. Information can be obtained at the Centers Web site: http://www.reproduction.wsu.edu. Research: The overall research goal of the program is to develop an understanding of the reproductive toxicology of endocrine disruptors by evaluating and comparing four different non-human vertebrate model systems. The general hypothesis is that a comparative analysis of the reproductive toxicology of endocrine disruptors in four different vertebrate species will provide information that can be extrapolated to better understand actions on human health. The mechanistic program hypothesis is that endocrine disruptors (i.e. methoxychlor, vinclozolin and phthalates) influence embryonic gonadal development that results in abnormal germ cell differentiation which subsequently influences adult reproduction and is transgenerational through the germ line. Observations are anticipated to provide novel insight into the mechanism of action of endocrine disruptors. The work will primarily be done with tissue from non-human vertebrate classes (e.g. fish, amphibians, birds, and mammals) to increase the basic understanding of the toxicology of endocrine disruptors on male and female reproduction. Summary: A major societal concern that affects our
local region and the world is the influence environmental toxins (i.e.
endocrine disruptors) have on our environment and health. All animal populations
and species, including humans, are affected to some degree by these environmental
toxins. Perhaps the most sensitive biological process is the ability of
a species to reproduce. A collaborative Reproductive Toxicology program
is proposed to provide basic information on this problem and develop new
strategies and therapeutic treatments. The proposed program involves both
Washington State University and the University of Idaho. Over 10 faculty,
4 different departments and 3 colleges are represented in the program.
The program investigates the comparative reproductive toxicology of four
different vertebrate species, including mammals, birds, amphibians, and
fish. The research focuses on gonadal development and male and female
reproduction. Therefore, the proposed program addresses a critical area
in reproductive toxicology. The comparative approach will provide insight
into the basic mechanism of action of endocrine disruptors on reproduction
and be extrapolated to human health issues. Projects: Program 2 - Hubert Schwabl, Professor, WSU, "Effects of Endocrine Disruptors on Avian Development and Reproduction" Program 3 - Rolf Ingermann, Associate Professor, UI; Paul Verrell, Associate Professor, WSU; and James Nagler, Assistant Professor, UI, " Environmental Endocrine Disruptors and Reproductive Successes in Amphibians " Program 4 - James Nagler, Associate Professor, UI; Joe Cloud, Professor,
UI; Irv Schultz, Affiliate Professor, UI; and Gary Thorgaard, Professor,
WSU, "Endocrine Disruptors and Reproduction in Fish"
Epigenetic Transgenerational Actions of Endocrine
Disruptors Program
Organization: Utilizes the organization and existing structure of the Center for Reproductive Biology at Washington State University and the University of Idaho to administer and integrate the research program. Information can be obtained at the Centers Web site: http://www.reproduction.wsu.edu. Research: The overall research goal of the program is to develop an understanding of the epigenetic transgenerational actions of endocrine disruptors by evaluating and comparing the actions of four different endocrine disruptors. The general hypothesis is that analysis of the reproductive toxicology of four different endocrine disruptors will provide information that can be extrapolated to better understand actions on human health. The mechanistic program hypothesis is that endocrine disruptors (i.e. BPA, dioxin, vinclozolin and phthalates) influence embryonic gonadal development that results in abnormal germ cell differentiation which subsequently influences adult reproduction and is transgenerational through the germ line. Observations are anticipated to provide novel insight into the mechanism of action of endocrine disruptors. Summary: A major societal concern that affects our local region and the world is the influence environmental toxins (i.e. endocrine disruptors) have on our environment and health. All animal populations and species, including humans, are affected to some degree by these environmental toxins. Perhaps the most sensitive biological process is the ability of a species to reproduce. A collaborative Epigenetic Trasgenerational Endocrine Disruptor program is proposed to provide basic information on this problem and develop new strategies and therapeutic treatments. The program investigates the epigenetic transgenerational actions of four different endocrine disruptors. The research focuses on gonadal development and male and female reproduction. Therefore, the proposed program addresses a critical area in reproductive toxicology. The approach will provide insight into the basic mechanism of action of endocrine disruptors on reproduction and be extrapolated to human health issues.
Program 2 – Patricia Hunt, Professor, WSU, "Transgenerational BPA and oocyte chromosomal abnormalities" Program 3 – Paige Lawrence, Associate Professor, WSU, " Transgenerational dioxin actions on immune system " Program 4 – Kwan Hee Kim, Professor, WSU "Effects Of Phthalate Plasticizers During Mammalian Gonadal Development”
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