Assistant Professor Biological Sciences University of Idaho Moscow, ID 83844-3051 Phone: 208-885-7512 E-mail: manway@uidaho.edu   Ph.D., 2000, Washington State University   RESEARCH INTERESTS: Male reproductive tract aging, physiology and hormone regulation. RESEARCH SUMMARY: My research interest involves the study of male reproductive tract and hw alterations in development can lead to desease. We use embryonic exposures to enviromental toxins as a model to study how alterations in embryonic development lead to adult desease states. We study a class of enviromental fungicides and how they affect adult spermtogensis and prostate hyperplasia. We study secveral aspects of the adult male reproductive tract including aging, hormonal regulation and inheritance. REPRESENTATIVE PUBLICATIONS: Anway MD, Wright WW, Zirkin BR, Korah N, Mort JS, Hermo L. (2004) Expression and localization of cathepsin K in the adult rat testis. Biol Reprod. 70(3):562-569. Show MD, Folmer JS, Anway MD, Zirkin BR. (2004) Testicular expression and distribution of the rat Bcl2 modifying factor (BMF) in response to reduced intratesticular testosterone. Biol Reprod. 70(4):1153-1161. Hill CM, Anway MD, Zirkin BR, Brown TR. (2004) Intratesticular androgen levels, androgen receptor localization and androgen receptor expression in adult rat Sertoli cells. Biol Reprod. 71(4):1348-1358. Show MD, Anway MD, Zirkin BR. (2004) An ex vivo analysis of Sertoli cell actin dynamics following gonadotropic hormone withdrawal. J Androl. 25(6):1031-1021. Anway MD, Cupp AS, Uzumcu M, Skinner MK. (2005) Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science. 308(5727):1466-1469. Anway MD, Show MD, Zirkin BR. (2005) Protein c inhibitor expression by adult rat Sertoli cells: effects of testosterone withdrawal and repletion. J Androl. 26(5):578-585. Skinner MK, Anway MD. (2005) Seminiferous cord formation and germ-cell programing: epigenetic transgenerational actions of endocrine disruptors. Ann NY Acad Sci. 1061:18-32. Luo L, Chen H, Trush MA, Show MD, Anway MD, Zirkin BR. (2006) Aging and the brown Norway rat Leydig cells antioxidant defense system. J Androl. 27(2):240-247. Anway MD, Skinner MK. (2006) Epigenetic transgenerational actions of endocrine disruptors. Endocrinology. 147(6 Supplemental):S43-S49. Anway MD, Memon MA, Uzumcu M, Skinner MK. (2006) Transgenerational effect of the endocrine disruptor vinclozolin on male spermatogenesis. J Androl. 27(6):868-79. Anway MD, Leathers C, Skinner MK. (2006) Endocrine disruptor vinclozolin induced epigenetic transgenerational adult onset disease. Endocrinology. 147(12):5512-5523. Chang HS, Anway MD, Rekow SS, Skinner MK. (2006) Transgenerational epigenetic reprogramming of the male germ-line by endocrine disruptor exposure during gonadal sex determination. Endocrinology. 147(12):4424-5541. Crews D, Gore AC, Hsu TS, Dangleben NL, Spinetta M, Schallert T, Anway MD, Skinner MK. (2007) Transgenerational epigenetic imprints on mate preference. Proc Natl Acad Sci USA. 104(14):5942-5946. Clement TM, Anway MD, Uzumcu M, Skinner MK, (2007) Regulation of the gonadal transcriptome during sex determination and testis morphogenesis: comparative candidate genes. Reproduction. 134:455-472.