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Phone: 509-335-5040 Fax: 509-335-5043 Email:craft@wsu.edu Ph.D. - Exp’l & Biological Psychology, University of North
Carolina – 1991 RESEARCH INTERESTS: Sex differences in pain and analgesia.
RESEARCH SUMMARY: One research focus in my lab is determining the relationship between gonadal hormone modulation of reproductive behavior vs. pain-related behavior. Although hormones like testosterone and estrogen are typically thought of as reproductive hormones, they also modulate sensitivity to pain and analgesia, in part by modulating the endogenous opioid system. Our goal is to determine where and how gonadal hormones act in the nervous system to modulate sensitivity to pain and analgesia.Another focal point of my research is developing an animal model of post-partum depression. The dramatic drop in gonadal hormones during the post-partum period is believed to be the trigger for major depression that occurs in ~10-15% of new mothers; post-partum hormonal changes may also contribute to dysthymia, or “baby blues” that occurs in an even larger portion of new mothers. My lab is currently examining whether we can use hormone-stimulated pregnancy to induce depression-like and anxiety-like behaviors in female rats after termination of hormone administration, and if so, whether various hormone and standard anti-depressant treatments can reverse these behaviors. The ultimate goals of this line of research are to discover the neurobiological mechanism of post-partum depression and to improve the treatment outcomes for the women who suffer from it.
REPRESENTATIVE PUBLICATIONS: Craft RM. (2005) Sex differences in behavioral effects of cannabinoids. Life Sci. 77(20):2471-8. Stoffel EC, Ulibarri CM, Folk JE, Rice KC, Craft RM. (2005) Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats. J Pain. 6(4):261-74. Craft RM, Lee DA. (2005) NMDA antagonist modulation of morphine antinociception in female vs. male rats. Pharmacol Biochem Behav. 80(4):639-49. Stoffel EC, Craft RM. (2004) Ovarian hormone withdrawal-induced "depression" in female rats. Physiol Behav. 83(3):505-13. Craft RM, Mogil JS, Aloisi AM. (2004) Sex differences in pain and analgesia: the role of gonadal hormones. Eur J Pain. 8(5):397-411. Tseng AH, Harding JW, Craft RM. (2004) Pharmacokinetic factors in sex differences in Delta 9-tetrahydrocannabinol-induced behavioral effects in rats. Behav Brain Res. 154(1):77-83. Craft RM, Morgan MM, Lane DA. (2004) Oestradiol dampens reflex-related activity of on- and off-cells in the rostral ventromedial medulla of female rats. Neuroscience. 125(4):1061-8. Tseng AH, Craft RM. (2004) CB(1) receptor mediation of cannabinoid behavioral effects in male and female rats. Psychopharmacology (Berl). 172(1):25-30. Craft RM. (2003) Sex differences in opioid analgesia: "from mouse to man". Clin J Pain. 19(3):175-86. Stoffel EC, Ulibarri CM, Craft RM. (2003) Gonadal steroid hormone modulation of nociception, morphine antinociception and reproductive indices in male and female rats.Pain. 103(3):285-302. Craft RM, McNiel DM. (2003) Agonist/antagonist properties of nalbuphine, butorphanol and (-)-pentazocine in male vs. female rats. Pharmacol Biochem Behav. 75(1):235-45. Craft RM. (2003) Sex differences in drug- and non-drug-induced analgesia.
Craft RM, Tseng AH, McNiel DM, Furness MS, Rice KC. (2001) Receptor-selective antagonism of opioid antinociception in female versus male rats. Behav Pharmacol. 12(8):591-602.
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