Terry Hassold Professor School of Molecular Biosciences Washington State University Pullman, WA 99164-4660   Phone: 509-335-5537 Fax: 509-335-9688 Email:terryhassold@wsu.edu   Ph.D. Michigan State University ­ Human Genetics, 1977 M.S. Michigan State University ­ Human Genetics, 1972 B.S. Michigan State University ­ Zoology, 1968 RESEARCH INTERESTS: Chromosome abnormality in pregnancy.   RESEARCH SUMMARY: Over 50% of all human pregnancy loss is attributed to chromosome imbalance in the fetus, making chromosome abnormalities the leading cause of reproductive failure. One of the primary aims of my laboratory is the use of cytogenetic and molecular techniques to study the origin and etiology of human chromosome abnormalities, with the aim being to uncover basic mechanisms responsible for the errors.   REPRESENTATIVE PUBLICATIONS: Brown, P. W., Judis, L., Chan, E. R., Schwartz, S., Seftel, A., Thomas, A., and Hassold, T. J. (2005). Meiotic synapsis proceeds from a limited number of subtelomeric sites in the human male. Am J Hum Genet 77, 556-66. Hodges, C. A., Revenkova, E., Jessberger, R., Hassold, T. J., and Hunt, P. A. (2005). SMC1beta-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction. Nat Genet 37, 1351-5. Lamb, N. E., Sherman, S. L., and Hassold, T. J. (2005). Effect of meiotic recombination on the production of aneuploid gametes in humans. Cytogenet Genome Res 111, 250-5. Lynn, A., Schrump, S., Cherry, J., Hassold, T., and Hunt, P. (2005). Sex, not genotype, determines recombination levels in mice. Am J Hum Genet 77, 670-5. Mann, M. B., Hodges, C. A., Barnes, E., Vogel, H., Hassold, T. J., and Luo, G. (2005). Defective sister-chromatid cohesion, aneuploidy and cancer predisposition in a mouse model of type II Rothmund-Thomson syndrome. Hum Mol Genet 14, 813-25 Cherry SM, Hunt PA, Hassold TJ. (2004) Cisplatin disrupts mammalian spermatogenesis, but does not affect recombination or chromosome segregation. Mutat Res. 564(2):115-28. Koehler KE, Millie EA, Cherry JP, Schrump SE, Hassold TJ. (2004) Meiotic exchange and segregation in female mice heterozygous for paracentric inversions. Genetics. 166(3):1199-214. Hunt PA, Koehler KE, Susiarjo M, Hodges CA, Ilagan A, Voigt RC, Thomas S, Thomas BF, Hassold TJ. (2003) Bisphenol a exposure causes meiotic aneuploidy in the female mouse. Curr Biol. 13(7):546-53. Koehler KE, Millie EA, Cherry JP, Burgoyne PS, Evans EP, Hunt PA, Hassold TJ. (2002) Sex-specific differences in meiotic chromosome segregation revealed by dicentric bridge resolution in mice. Genetics. 162(3):1367-79. Koehler KE, Cherry JP, Lynn A, Hunt PA, Hassold TJ. (2002) Genetic control of mammalian meiotic recombination. I. Variation in exchange frequencies among males from inbred mouse strains. Genetics. 162(1):297-306. Bean CJ, Hassold TJ, Judis L, Hunt PA. (2002) Fertilization in vitro increases non-disjunction during early cleavage divisions in a mouse model system. Hum Reprod. 17(9):2362-7. Hunt PA, Hassold TJ. (2002) Sex matters in meiosis. Science. 296(5576):2181-3. Review. Lynn A, Koehler KE, Judis L, Chan ER, Cherry JP, Schwartz S, Seftel A, Hunt PA, Hassold TJ. (2002) Covariation of synaptonemal complex length and mammalian meiotic exchange rates. Science. 296(5576):2222-5. Hassold TJ, Burrage LC, Chan ER, Judis LM, Schwartz S, James SJ, Jacobs PA, Thomas NS. (2001) Maternal folate polymorphisms and the etiology of human nondisjunction. Am J Hum Genet. 69(2):434-9. Bean CJ, Hunt PA, Millie EA, Hassold TJ. (2001) Analysis of a malsegregating mouse Y chromosome: evidence that the earliest cleavage divisions of the mammalian embryo are non-disjunction-prone. Hum Mol Genet. 10(9):963-72. Thomas NS, Ennis S, Sharp AJ, Durkie M, Hassold TJ, Collins AR, Jacobs PA. (2001) Maternal sex chromosome non-disjunction: evidence for X chromosome-specific risk factors. Hum Mol Genet. 10(3):243-50. Thomas NS, Collins AR, Hassold TJ, Jacobs PA. (2000) A reinvestigation of non-disjunction resulting in 47, XXY males of paternal origin. Eur J Hum Genet. 8(10):805-8. Hixon ML, Obejero-Paz C, Muro-Cacho C, Wagner MW, Millie E, Nagy J, Hassold TJ, Gualberto A. (2000) Cks1 mediates vascular smooth muscle cell polyploidization. J Biol Chem. 275(51):40434-42. LePage DF, Church DM, Millie E, Hassold TJ, Conlon RA. (2000) Rapid generation of nested chromosomal deletions on mouse chromosome 2. Proc Natl Acad Sci U S A. 97(19):10471-6. Robinson WP, Christian SL, Kuchinka BD, Penaherrera MS, Das S, Schuffenhauer S, Malcolm S, Schinzel AA, Hassold TJ, Ledbetter DH. (2000) Somatic segregation errors predominantly contribute to the gain or loss of a paternal chromosome leading to uniparental disomy for chromosome 15. Clin Genet. 57(5):349-58. Zaragoza MV, Surti U, Redline RW, Millie E, Chakravarti A, Hassold TJ. (2000) Parental origin and phenotype of triploidy in spontaneous abortions: predominance of diandry and association with the partial hydatidiform mole. Am J Hum Genet. 66(6):1807-20.