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RESEARCH INTERESTS: Reproductive Cancers RESEARCH SUMMARY: We utilize genetic engineering, biomolecular engineering, bioengineering, cell biology, and polymeric gene/drug delivery to create systems that can be programmed to perform multiple functions. Our main goal is to design a delivery system that can be programmed to evade the immune system, adapt to its environment, find its target and deliver therapeutically relevant molecules to the target cells with high efficiency/toxicity ratio. REPRESENTATIVE PUBLICATIONS: A. Hatefi, Z. Megeed, H. Ghandehari, A Recombinant Protein-Polymer Fusion: A Promising Approach towards Efficient and Targeted Gene Delivery. J. Gene Med. 8: 468-476 (2006). M. Haider, A. Hatefi, H. Ghandehari, Recombinant Polymers for Cancer Gene Therapy. J. Controlled Release, 109: 108-119 (2005). A. Hatefi, D. Knight, and B. Amsden. A Biodegradable Injectable Thermoplastic for Localized Camptothecin Delivery, J. Pharm. Sci., 93:1195–1204 (2004). B. Amsden, A. Hatefi, D. Knight and E. Bravo-Grimaldo. Development of biodegradable injectable thermoplastic oligomers. Biomacromolecules, 5:637-642 (2004). A. Hatefi, and B. Amsden. Biodegradable Injectable In-Situ Forming Drug Delivery Systems, J. Controlled Release, 80:9-28 (2002). A. Hatefi, and B. Amsden. Camptothecin Delivery Methods, Pharm. Res., 19:1387-1397 (2002). A. Hatefi, and M.R. Tehrani. Characterization and evaluation of enteric-coated controlled release tablet formulations of diclofenac sodium, Acta Pharmaceut, 46:285-294 (1996). PATENT |
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