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RESEARCH INTERESTS: Mammary Physiology RESEARCH SUMMARY: Our research makes use of several strategies to investigate the mechanisms of breast cancer development. Innovative new tissue culture methods have been used extensively in these studies. We have recently identified a new type of transforming growth factor that influences the earliest steps in tumor development. Interestingly, the production of this and related growth factors is distinctly different in older individuals. This observation may provide significant clues as to why most cancer is a disease of old age. We are developing gene therapy strategies for manipulating levels of this factor in breast cancer patients. Collaboartive research now underway includes development of 'neurticeuticals'; studies of how tumor cells influence blood vessel growth; and dvelopment of ceramic scaffolds for tissue repair and replacemetnt.
REPRESENTATIVE PUBLICATIONS: Mealey, K., Bentjen, S.A., Gay, J.M. and Hosick, H.L., 2003. Dexamethasone treatment of canine osteosarcoma cells increases chemoresistance independent of P-glycoprotein and MRP expression. Cancer Chemother. Pharmacol. J. Vet. Comp. Oncology 12: 67-75. Kalita, S.J., Bose, S., Hosick, H.L. and Bandyopadhyay, 2003. Development of controlled porosity polymer- ceramic composite scaffolds using fused deposition modeling. Materials Sci. Engineering C vol. 23: 611- 620. Kalita, S., Finley, J., Bose, S., Hosick, H.L. and Bandyopadhyay, A., 2003. Development of porous polymer- ceramic composites as bone grafts. Proc. Materials Res. Soc. on Organic-Inorganic Materials 724: Symposium Q5.8. Kalita, S.J., Bose, S.,. Hosick, H.L. Martinez, S.A. and Bandyopadhyay, A., 2003. Calcium carbonate reinforced natural polymer composites for bone grafts. Proc. Materials Res. Soc. Symp.on Organic- Inorganic Materials 726: Symposium Q5.8. Kalita, S.J., Hosick, H.L., Martinez, S.A., Bandyopadhyay, A. and Bose, S., 2003. Characterization of calcium carbonate reinforced castor bean extract natural polymer composites for bone graft applications. Proc. Materials Res. Society 726: Symposium Q5.8. Kalita, S.J., Bose,
S., Hosick, H.L. and Bandyopadhyay, A., Xing, P.X., Hu, X.F., Pietersz, G.A., Hosick, H. and McKenzie, I.F.C., 2004. Cripto-1: a novel target for cancer therapy by monoclonal antibodies. Cancer Res. 64: 4018-4023. S. J. Kalita, D. Rokusek, S. Bose, H. L. Hosick and A. Bandyopadhyay, 2004. Effects of MgO-CaO-P2O5- Na2O-based additives on mechanical and biological properties of hydroxyapatite. Journal of Biomedical Materials Research, 71A [1]: 35-44. Rokusek, D., Davitt, C., Bandyopadyay, A., Bose, S. and Hosick, H., 2005. Interaction of human osteoblasts with bioinert and bioactive ceramic substrates. J. Biomed. Biomaterials Res. (accepted) Moore, J.L., Xue, W., Hosick, H.L. Bose, S., and Bandyopadhyay, A.,2006. Interaction of human osteoblasts with bioinert and bioactiveceramic substrates. Journal of Biomedical Materials Research: Part A.(accepted). Xue, W., Moore, J.L., Hosick, H.L., Bose, S., Bandyopadhyay, A., Lu,W.W., Cheung, K.M.C. and Luk,K.D.K., 2006. Osteoprecursor cell responseto strontium-containing hydroxyapatite. (submitted)
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