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RESEARCH INTERESTS: Reproductive Immunology/Biochemistry RESEARCH SUMMARY: My interests in inflammation, cytokines, and inflammatory
mediators of macrophages, most particularly bovine alveolar macrophages,
have led me to initiate a new collaborative research area focusing
on these molecules and fetal and maternal macrophages during
bovine gestation. My laboratory has developed an extensive methodology
for characterizing macrophage function, including: arachidonate
metabolism, particle uptake, bactericidal activity, and cell
surface complement regulatory proteins. Although the publications
listed below reflect only bovine alveolar macrophage mediators.
The technology can be applied readily to maternal and fetal macrophages.
In the long-term, survival of the fetus, the chemical signalling
between these important macrophage subpopulations are critical
for survival.
REPRESENTATIVE PUBLICATIONS: Dernell, W.S., L.G. Wheaton, P.R. Gavin, C.W. Leathers, and R. Wes. Leid (1994). Thromboxane as a measure of cutaneous vascular damage following irradiation. Plastic and Reconstructive Surgery 93: 1465-1472. Basaraba, R.J., P.R. Brown, R.M. Silflow, W.W. Laegreid, and R. Wes. Leid (1994). Cell- Cell Contact Not Soluble Factors Mediate Suppression of Lymphocyte Proliferation by Bovine Parainfluena Virus Type 3. Viral Immunology 7:121-132. Basaraba, R.J., P.R. Brown, W.W. Laegreid, R.M. Silflow, J.R. Evermann, and R. Wes Leid (1993). Suppression of lymphocyte proliferation by parainfluenza virus type 3 infected bovine alveolar macrophages. Immunology 79:179-188. Leid, R. Wes, I van der Heijden, B.E.P.B. Ballieux, C. Kleyburg-van der Keur, E.C. Hagen, L.A. van Es, F.J. van der Woude, and M.R. Daha (1993). Cleavage and inactivation of human C1-inhibitor by the human leukocyte proteinase, proteinase 3. Eur. J. Immunol. 23:2039-2944. Silflow, R.M., B. Foreyt, and R. Wes. Leid (1993). Pasteurella hemolytica Cytotoxin Dependent Killing of Neutrophils from Bighorn and Domestic Sheep. J. Wildlife Dis. 29: 30-35. Aydintug, M.K., P.R. Widders, and R. Wes. Leid (1993). Trichomonacidal Activity of Bovine Neutrophils for Tritrichomonas foetus. Infection and Immunity 61: 2995-3002. |
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