Professor and Animal Scientist Dept.of Animal Sciences and Nutrition Program Washington State University Pullman WA 99164-6320   Phone: 509-335-4113 FAX: 509-335-4246 E-mail: mcnamara@wsu.edu    Ph.D. 1982 University of Georgia RESEARCH INTERESTS: Lactation Mammary Biology RESEARCH SUMMARY: The objective of my program is to define the endocrine and biochemical regulation of nutrient metabolism during lactation. Past work has included endocrine regulation of adipose tissue metabolism, mammary development and lactogenesis. Present focus is on sympathetic and adrenergic regulation of lipolysis in lactation. Data are used to construct and challenge bio-mathematical models integrating metabolism in the whole animal. Gene chip array analysis results are being integrated into metabolic models, and a mechanistic model of nutrient use and reproduction is being constructed and evaluated. Animal models studied include dairy cattle, pigs, and rats; the latter two serve as models of human metabolism as well.   REPRESENTATIVE PUBLICATIONS: Hanigan, M. D., H. G. Bateman, J. G. Fadel, and J. P. McNamara. 2006. Metabolic Models of Ruminant Metabolism: Recent Improvements and Current Status. J. Dairy Sci. 89: E52-64E. McNamara, J. P. 2006. Modelling metabolism in the lactating sow: mechanistic modelling at the metabolic level. In: Pig and Poultry Modeling, Symposium, South Africa, April, 2005, in press. McNamara, J. P., 2006. Metabolic control: Improvement of a dynamic model of lactational metabolism in early lactation. International Workshop on Modelling Nutrient Utilization. Pp 349-365, Chapter 30 in Proceedings of 6th International workshop on modelling in farm animals. CAB International, UK. Hanigan, M.D., H. G. Bateman, J. G. Fadel, J. P. McNamara, N.E. Smith 2006. An ingredient-based input scheme for Molly. International Workshop on Modelling Nutrient Utilization. Pp 328-348, Chapter 29 in Proceedings of 6th International workshop on modelling in farm animals. CAB International, UK. Jiang, Z., X.-L. Wu, J. J. Michal, and J. P. McNamara. 2005. Pattern profiling and mapping of the fat body transcriptome in Drosophila melanogaster. Obesity Research 13(11):1898-1904. International Workshop on Modelling Nutrient Utilization. CAB International, In press. McNamara, J.P., Valdez, F. 2005. Effects of dietary chromium propionate and calcium propionate on adipose tissue metabolism and milk production of dairy cattle in the transition period. J. Dairy Sci. 88: 2498-2507. McNamara, J.P. 2005. Research, Improvement and application of mechanistic, biochemical, dynamic models: from Genetics to Kinetics. Chapter 6 In: Mathematical modelling in nutrition and Toxicology. Proceedings of the 8th International Conference on Mathematical Modeling in Nutrition and Health Science. Georgia Center for Continuing Education, pp 87-110. Mathematical Biology Press. ISBN 1-4116-2594-3. McNamara, J. P. 2004. Research, improvement and application of mechanistic, biochemical, dynamic models of metabolism in lactating dairy cattle. Animal Feed Science & Technology 112:155-176 McNamara, J. P. 2003. A perspective on research and future of metabolic models of farm animals. In: Progress in research on energy and protein metabolism., W. B. Souffrant and C C. Metges, eds. EAAP Publication No.109, pp 99-112. McNamara, J. P. 2003. A perspective on research and future of metabolic models of farm animals. In: Progress in research on energy and protein metabolism., W. B. Souffrant and C C. Metges, eds. EAAP Publication No.109, pp 99-112. G. J. Phillips, T. L. Citron, J. S. Sage, K. A. Cummins, M. J. Cecava, and J. P. McNamara. 2003. Adaptations in body muscle and fat in transition dairy cattle fed differing amounts of protein and methionine hydroxy analog. J. Dairy Science 86:3634-3647. McNamara, J. P. and J. M. Gay (2002). Metabolic Diseases: Acidosis/Laminitis. In: Encyclopedia of Dairy Sciences, Pp 843-849. McNamara, J. P. (2002) Body Condition Score, Techniques and Measures. In: Encyclopedia of Dairy Sciences, Pp 163-168. McNamara, J. P. (2002). Body Condition Score, Effects on health, milk production and reproduction. In: Encyclopedia of Dairy Sciences. Pp168-173. McNamara JP, Pettigrew JE. (2002) Protein and fat utilization in lactating sows: I. Effects on milk production and body composition. J Anim Sci. 80(9):2442-51. McNamara, J. P., C. Murray. 2001. Sympathetic nervous system activity in adipose tissues during pregnancy and lactation of the rat. Journal of Dairy Science, 84:1382-1389. McNamara, J. P. 2000 Integrating Genotype and Nutrition on Utilisation of Body Reserves During Lactation of Dairy Cattle. In. Symposium on Ruminant Physiology. Pp 353-370, Cronje, P. B. , ed. CAB International, McNamara, J.P. and Baldwin, R.L. (2000) Estimation of parameters describing lipid metabolism in lactation: challenge of existing knowledge described in a model of metabolism. J. Dairy Sci. 83:128-143. Kelson, A.B., McNamara, J.P., Pandey, A., Ryan, K.J., Dorie, M.J., McAfee P.A., Menke, D.R., Brown, J.M., Tracy, M. (1998) 1, 2, 4-Benzotriaine 1, 4 dioxides. An important class of hypoxic cytotoxins with antitumor activity. Anticancer Drug Des. 13:575-592. Dodson, M.V., Vierck, J.L., Hossner, K.L., Byrne, K., McNamara J.P. (1997) The development and utility of a defined muscle and fat co-culture system. Tissue Cell. 29:517-524. McNamara, J.P. (1997) Adipose tissue metabolism during lactation: where do we go fom here? Proc Nutr Soc. 56:149-167. King, R.H., J.E. Pettigrew, J.P. McNamara, J.P. McMurtry, T.L. Henderson, M.R. Hathaway, and A.F. Sower (1996). The effect of exogenous prolactin on lactation performance of first-litter sows given protein-deficient diets during first pregnancy. Anim. Repro. Sci. 41:37-50. McNamara, J.P. (1995). Role and Regulation of Adipose Tissue Metabolism During Lactation. J. Nutr. Bioc. 6:120-129. Leisman, J.S., J.P. McNamara, A.V. Capuco, M. Binelli, W.K. Vanderkooi, R.S. Emery, H.A. Tucker, and W.M. Moseley (1995). Comparison of growth-hormone releasing factor and somatotropin: lipid and glucose metabolism in dairy cows. J. Dairy Sci. 78:2159-2166. Baldwin, R.L., R.S. Emery, and J.P. McNamara (1994). Metabolic Relationships in the Supply of Nutrients for Milk Protein Synthesis: Integrative Modeling. J. Dairy Sci. 77:2821-2836. Pettigrew, J.E., J.P. McNamara, M.D. Tokach, R.H. King, and B.A. Crooker (1993). Metabolic connections between nutrient intake and lactational performance. Livestock Prod. Sci. 35:137-152. Marinchenko, G.V., J.P. McNamara, S. Sun, and B. Becker-Khaleel (1992). Growth hormone alters metabolic effects and proteolysis of insulin in adipose tissue during lactation. Proc. Soc. Exp. Biol. Med. 200:57-66. Davis, S.R., R.J. Collier, J.P. McNamara, H.H. Head, W.J. Croom, and C.J. Wilcox (1988). Effects of thyroxine and growth hormone treatment of dairy cows on mammary uptake of glucose, oxygen, and other milkfat precursor. J. Anim. Sci. 66:80-89. Pocius, P.A., C.R. Baumrucker, , and D.E. Bauman (1980). Y-glutamyl transpeptidase activity in rat mammary tissue: changes during lactogenesis and possible role in amino acid transport for milk protein synthesis. Biochem. J. 188:565.