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RESEARCH INTERESTS: Lipid mediators in human reproductive cancers.
RESEARCH SUMMARY: My research interests lie in fundamental mechanisms of cellular signal
transduction. In particular, my laboratory has expertise in phospholipids
metabolism and protein phosphorylation cascades. My laboratory is investigating
the role of lysophosphstidic acid (LPA) in prostate, ovarian, and breast
cancer cells. Specifically, we are studying the pathways involved in LPA
generation and response. While there is strong eveidence that LPA is over-produced
in ovarian cancer, this mediator also appears to play an autocrine/paracrine
role in a wide variety of mammaliam cells. One of my research goals is
to study additional aspects of the role of LPA in the development and
function of reproductive tissue. REPRESENTATIVE PUBLICATIONS: Zhang, Z., Liu, Z., and Meier, K.E. (2006) Lysophosphatidic acid as a mediator for pro-inflammatory agonists in a human corneal epithelial cell line. Am. J. Physiol. Cell Physiol, in press. Xie, Y., Gibbs, T.C., and Meier, K.E. (2002) Lysophosphatidic acid as an autocrine and paracrine mediator. Biochim. Biophys. Acta, 1582: 270-281. Xie, Y.,Gibbs, T.C., Mukhin, Y., and Meier, K.E. (2002) Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells. J. Biol. Chem. 277: 32516-32526. Xie, Y., and Meier, K.E. (2001) Assays for phospholipase D metabolites in mammalian cells. Meth. Enzymol. 344: 294-305. Gibbs, T.C. and Meier, K.E. (2000) Expression and regulation of phospholipase D isoforms in mammalian cell lines. J. Cell Physiol. 182: 77-87. Gibbs, T.C., Xie, Y., and Meier, K.E. (2000) Regulation of expression of Edg family receptors in human prostate cancer cell lines. Ann. N.Y.A.S. 905: 290-293. Ku, H., and Meier, K.E. (2000) Phosphorylation of paxillin
via the ERK mitogen-activated protein kinase cascade in EL4 thymoma
cells. J. Biol. Chem. 275: 11333-11340.
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