Robert Bogden President & CEO Amplicon Vaccine, LLC & Amplicon Express Inc. 2345 NE Hopkins Court Pullman, WA 99163     Phone: 509-332-8080 Fax: 509-332-6338 Email: bogden@genomex.com   BA., 1992, University of Utah RESEARCH INTERESTS: RESEARCH SUMMARY: Amplicon Vaccine licensed a cloned LHRH (Luteinizing Hormone Releasing Hormone) chimeric, reproduction control vaccine technology from WSURF (Washington State University Research Foundation) reproductive. Through a strong collaboration with Dr. Jerry Reeves lab and joint funding through WTC (Washington Technology Center), a wide variety of pre-clinical studies have been performed including: ~300 bulls in Brazil, hundreds of mice/rats, heifers, sheep, goats and elephants to name a few. Currently studies are underway at WSU in mice to validate a single injection system (important for applications in wild/feral animals). In 2006, I raised $500K in Angel Investment for the company and licensed the technology to a firm interested in a couple species in Africa. Currently, there are discussions with other groups for specific applications (at various stages of negotiation). The collaborative work with Dr. Reeves team has resulted in a suite of peer reviewed publications and graduate student degrees. Please see the website www.amplicon-vaccine.com for details and a complete publication list on this technology. REFEREED PUBLICATIONS Hernandez JA, Zanella EL, Bogden R, de Avila DM, Reeves JJ. Reproductive characteristics of grass-fed, luteinizing hormone-releasing hormone-immunocastrated Bos indicus bulls. Journal of Animal Science 2005;83(12):2901-7. Riccardo Velasco, R….(48 authors)…, Lanchbury, J., Bogden R., Skolnick M., Sgaramella V., Bhatnagar S., Fontana1 P., Gutin A.,Van de Peer Y., Salamini F., Viola, R., A High Quality Draft Consensus Sequence of the Genome of a Heterozygous Grapevine Variety PLoS ONE 2007;December, Issue 12:e1326. Teng, D., Bogden, R., Mitchell, J., Baumgard M., Bell R., Berry, S., Davis, T., Ha, P., Kehrer, R., Jammulapati, S., Chen, Q., Offit, K., Skolnick, M., Tavtigian, S., Jhanwar, S., Swedlund, B., Wong, A., Kamb, A., Low incidence of BRCA2 mutations in breast carcinoma and other cancers, Nature Genetics Volume 13, 241-244 (1996). Couch, F., Farid, L., DeShano, M., Tavtigian, S., Calzone, K., Campeau, L., Peng, Y., Bogden, R., Chen, Q.,..(10 authors).. Weber, B., BRCA2 germline mutations in male breast cancer cases and breast cancer families, Nature Genetics Volume 13, 123-125 (1996). Couch FJ, Rommens JM, Neuhausen SL, Belanger C, Dumont M, Abel K, Bell R, Berry S, Bogden R, Cannon-Albright L, Farid L, Frye C, Hattier T, Janecki T, Jiang P, Kehrer R, Leblanc JF, McArthur-Morrison J, McSweeney D, Miki Y, Peng Y, Samson C, Schroeder M, Snyder SC, Stringfellow M, Stroup C, Swedlund B, Swensen J, Teng D, Thakur S, Tran T, Tranchant M, Weaver-Feldhaus J, Wong AKC, Shizuya H, Labrie F, Skolnick MH, Goldgar DE, Kamb A, Weber BL, Tavtigian SV, Simard J., Generation of an integrated transcription map of the BRCA2 region on chromosome 13q-12-q13. Genomics 1996 36: 86-89. Tavtigian SV, Simard J, Rommens J, Couch F, Shattuck-Eidens D, Neuhausen S, Merajver S, Thorlacius S, Offit K, Stoppa-Lyonnet D, Belanger C, Bell R, Berry S, Bogden R, Chen Q, Davis T, Dumont M, Frye C, Hattier T, Jammulapati S, Janecki T, Jiang P, Kehrer R, Leblanc JF, Mitchell JT, McArthur-Morrison J, Nguyen K, Peng Y, Samson C, Schroeder M, Snyder SC, Steele L, Stringfellow M, Stroup C, Swedlund B, Swensen J, Teng D, Thomas A, Tran T, Tran T, Tranchant M, Weaver-Feldhaus J, Wong AKC, Shizuya H, EyfjordJE, Cannon-Albright L, Labrie F, Skolnick MH, Weber B, Kamb A, Goldgar DE., The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds. Nature Genetics 1996 March; Vol. 12 (3): 333-337. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, Bell R, Rosenthal J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano A, Katcher H, Yakumo K, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J, Tonin P, Narod S, Bristow PK, Norris F, Helvering L, Morrison P, Rosteck P, Lai M, Barrett JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb A, Skolnick MH., A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 1994 October; 266 (5182): 66-71.