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Research Interests
Fish Reproduction/Toxicology
Research Summary
The research focus of the Nagler lab is reproductive biology of fishes, with an emphasis on salmonids. A major study seeks to understand the endocrine events that coordinate fish gonadal development. This collaborative effort involving scientists at Ohio State University, the University of Wisconsin, and the Battelle Marine Sciences Laboratory, is modeling the genes involved in the brain-pituitary-gonad axis regulating reproduction in female rainbow trout. Another project is looking at how environmental estrogens, contaminants that mimic estradiol, affect reproduction in the male rainbow trout. A recent publication in the Proceedings of the National Academy of Science demonstrated that the environmental estrogen ethynylestradiol can cause increased sperm aneuploidy levels in exposed males that resulted in embryonic aneuploidy and mortality. Another active project is the pathway of molecular sex determination and differentiation in the rainbow trout. Lastly, the Nagler lab, in collaboration with Troutlodge Inc., continues to work on understanding the mechanism for sub-fertility which occurs in a significant proportion of female rainbow trout brood stocks used for production aquaculture.
Research Publications
2005-2009
Liu, Y., J. Verducci, I. Schultz, S. Hook, J. Nagler, G. Craciun, K. Sundling, W. Hayton (2009) Time course analysis of microarray data for the pathway of reproductive development in female rainbow trout. Stat. Anal.Data Mining 2(3):192-208.
Cavileer, T., S. Hunter, T. Okutsu, G. Yoshizaki, J.J. Nagler (2009) Identification of novel genes associated with molecular sex differentiation in the embryonic gonads of rainbow trout (Oncorhynchus mykiss). Sexual Develop. 3:214-224.
Boyce-Derricott, J., J.J. Nagler, and J.G. Cloud (2009) Regulation of hepatic estrogen receptor isoform mRNA expression in rainbow trout (Oncorhynchus mykiss). Gen. Comp. Endocrinol. 161(1):73-8.
Brown, K.H., I.R. Schultz, and J.J. Nagler (2009) Lack of a heritable reproductive defect in the offspring of male rainbow trout exposed to the environmental estrogen 17alpha-ethynylestradiol. Aquat. Toxicol. 91(1):71-4.
Brown, K.H., I.R. Schultz, J.G. Cloud, and J.J.
Nagler (2008) Aneuploid sperm formation in rainbow trout
exposed to the environmental estrogen 17alpha-ethynylestradiol.
Proc. Natl. Acad. Sci. USA, 105(50):19786-91.
Schultz, I.R., K.H. Brown, and J.J. Nagler
(2008) Effect of parental exposure to trenbolone and BDE-47 on
fertility in rainbow trout (Oncorhynchus mykiss). Mar. Environ.
Res. 66:47-49.
Brown, K.H., I.R. Schultz, and J.J. Nagler
(2007) Reduced embryonic survival in rainbow trout resulting from
paternal exposure to the environmental estrogen
17alpha-ethynylestradiol during late sexual maturation.
Reproduction 134(5):659-66.
Nagler, J.J., T. Cavileer, J. Sullivan, D.G.
Cyr, and C. Rexroad III (2007) The complete nuclear estrogen
receptor family in the rainbow trout: discovery of the novel
ERalpha2 and both ERbeta isoforms. Gene 392(1-2):164-73.
de Montgolfier, B., J. Dufresne, M. Letourneau, J.J.
Nagler, A. Fournier, C. Audet, and D.G. Cyr (2007) The
expression of multiple connexins throughout spermatogenesis in the
rainbow trout testis suggests a role for complex intercellular
communication. Biol. Reprod. 76:2-8.
Skillman, Ann D., James J. Nagler, Sharon E. Hook,
Jack A. Small, and Irvin R. Schultz (2006) Dynamics of
17α-ethynylestradiol exposure in rainbow trout (Oncorhynchus
mykiss): absorption, tissue distribution and hepatic gene
expression. Environ. Tox. Chem. 25:2997-3005.
Stoddard, J.W., J.E. Parsons, and J.J. Nagler, Early onset of embryonic mortality in sub-fertile families of rainbow trout (Oncorhynchus mykiss). Reprod Fertil Dev, 2005. 17(8): p. 785-90.