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Research Interests
Lipid mediators in human reproductive cancers.
Research Summary
My research interests lie in fundamental mechanisms of cellular signal transduction. In particular, my laboratory has expertise in phospholipids metabolism and protein phosphorylation cascades. My laboratory is investigating the role of lysophosphstidic acid (LPA) in prostate, ovarian, and breast cancer cells. Specifically, we are studying the pathways involved in LPA generation and response. While there is strong eveidence that LPA is over-produced in ovarian cancer, this mediator also appears to play an autocrine/paracrine role in a wide variety of mammaliam cells. One of my research goals is to study additional aspects of the role of LPA in the development and function of reproductive tissue.
Research Publications
Zhang, Z., Liu, Z., and Meier, K.E. (2006) Lysophosphatidic acid as a mediator for pro-inflammatory agonists in a human corneal epithelial cell line. Am. J. Physiol. Cell Physiol, in press.
Xie, Y., Gibbs, T.C., and Meier, K.E. (2002) Lysophosphatidic acid as an autocrine and paracrine mediator. Biochim. Biophys. Acta, 1582: 270-281.
Xie, Y.,Gibbs, T.C., Mukhin, Y., and Meier, K.E. (2002) Role for 18:1 lysophosphatidic acid as an autocrine mediator in prostate cancer cells. J. Biol. Chem. 277: 32516-32526.
Xie, Y., and Meier, K.E. (2001) Assays for phospholipase D metabolites in mammalian cells. Meth. Enzymol. 344: 294-305.