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Research Interests
Lactation Mammary Biology
Research Summary
The objective of my program is to define the endocrine and biochemical regulation of nutrient metabolism during lactation. Work includes transcriptomic and endocrine regulation of adipose tissue metabolism in lactating cows and pigs. Present focus is on transcriptomic adaptations to lactation, control of adipose metabolic flux and cytokine production. Nutrigenomic data are used to integrate into bio-mathematical models integrating metabolism in the whole animal. Animal models studied include dairy cattle and pigs. Funding has come from NIH, USDA (CSREES), National Pork Producers Council, Washington State Dairy Products Commission, Hatch funds, and Private Industry.
Research Publications
2005-2009
McNamara, J.P. 2009. Nutrigenomics for
improved reproduction, Chapter 19 in Reproductive Genomics in
Domestic Animals by Jiang, Z. and T. Ott, eds. Elsevier
Schactschneider, C., Youngquist, A., Rocco, S. M., Vierck, J. L. and J. P. McNamara. 2009. Regulation of dairy cattle adipose tissue metabolism by adrenergic control systems and gene transcription mechanisms dictating increased overall efficiency. Proceedings of the 12th International Symposium on Ruminant Digestion and Physiology, Clermont-Ferrand eds:Y. Chilliard, F. Glasser, Y. Faulconnier, F. Bocquier, I. Veissier, M. Doreau, Wageningen Acad. Press.
Schactschneider, C., Youngquist, A., Rocco, S. M., Vierck, J. L.
and J. P. McNamara 2009. Using a dynamic metabolic
model to investigate patterns of nutrient flux in the most
efficient dairy animals and to integrate gene expression data into
metabolic control. Proceedings of the 7th International
workshop on modelling nutrient utilization in farm animals. Paris.
CABI
McNamara, J.P., ASAS Centennial Paper: The
future of teaching and research in companion animal biology in
departments of animal sciences. J Anim Sci, 2009. 87(1): p.
447-54.
Sumner, J. M. and J. P. McNamara 2007.
Expression of Beta-Adrenergic Receptors, Hormone Sensitive Lipase
and Perilipin in adipose tissue of pregnant and lactating Holstein
Dairy Cattle. Pp 105-106 in Energy and Protein Metabolism and
Nutrition, EAAP Pub. No. 124, Wageningen Academic Press,
Ortigues-Marty, I, N. Miraux, eds. 2007
McNamara, J. P. Jennifer M. Sumner and Jan
Vierck, Alyssa Jourdan. 2007. Gene expression in adipose tissue of
the dairy cow during late pregnancy and lactation fed control diets
or diets with supplemental chromium: integration of gene
expression into metabolic models. Pp 283-284 in Energy and
Protein Metabolism and Nutrition, EAAP Pub. No. 124, Wageningen
Academic Press, Ortigues-Marty, I, N. Miraux, eds.
2007
Sumner, J.M. and J.P. McNamara, Expression of lipolytic genes in the adipose tissue of pregnant and lactating Holstein dairy cattle. J Dairy Sci, 2007. 90(11): p. 5237-46.
Sumner, J.M., F. Valdez, and J.P. McNamara,
Effects of chromium propionate on response to an intravenous
glucose tolerance test in growing Holstein heifers. J Dairy Sci,
2007. 90(7): p. 3467-74.
Hanigan, M.D., H. G. Bateman, J. G. Fadel, J. P. McNamara, N.E. Smith 2006. An ingredient-based input scheme for Molly. Pp 328-348, Chapter 29 in: Nutrient Digestion and Utilization in Farm Animals. Modelling Approaches International Workshop on Modelling Nutrient Utilization. CAB International, UK.