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Research Interests
Sertoli Cell Function
Research Summary
For the past 15 years my research has been directed towards the understanding of mammalian spermatogenesis. We have concentrated our efforts on the delineation of the influence of the Sertoli cells on the process of germinal cell differentiation and maturation. Much of our interest has focused on the glycoproteins which are secreted by Sertoli cells and interact with a variety of germinal cells. We utilize a variety of molecular approaches in attempts to characterize the Sertoli-germ cell interaction at the molecular level. In addition, we are characterizing gene products and regulatory mechanisms that are unique to the somatic cells. For example, we identified transferrin as a Sertoli cell secretion product and described a process whereby Sertoli cells deliver iron from the testicular lymph to the spermatocytes and round spermatids. Similar types of studies on other Sertoli cell products are currently under way.
Research Publications
Koubova J, Menke DB, Zhou Q, Capel B, Griswold MD, Page DC. 2006 Retinoic acid regulates sex-specific timing of meiotic initiation in mice. Proc Natl Acad Sci USA. 103(8):2474-9.
Lee TH, Yi W, Griswold MD, Zhu F, Her C. 2006
Formation of hMSH4-hMSH5 heterocomplex is a prerequisite for
subsequent GPS2 recruitment. DNA Repair (Amst).5(1):32-42.
Li Y, Putnam-Lawson CA, Knapp-Hoch H, Friel PJ, Mitchell D, Hively
R, Griswold MD. 2005 Immunolocalization and
Regulation of Cystatin 12 in Mouse Testis and Epididymis. Biol
Reprod. 73(5):872-80.
Meng J, Holdcraft RW, Shima JE, Griswold MD, Braun
RE. 2005 Androgens regulate the permeability of the blood-testis
barrier. Proc Natl Acad Scie USA. 102(46):16696-700.