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Research Interests
Psychopharmacology, Hormone Modulation of Pain, Analgesia and
Mood
Research Summary
Using animal models, the broad research goals of the Craft laboratory are to determine (1) whether there are sex differences in the psychopharmacological effects of drugs; and (2) how gonadal steroid hormones such as testosterone and estradiol modulate pain, mood and the therapeutic and side-effects of psychoactive drugs. The clinical applications of this work are (1) the development of sex-appropriate guidelines for use of psychotherapeutic and analgesic medications; and (2) improved prevention and treatment of gonadal steroid hormone-mediated pain and depression.
Research Publications
2005-2009
Craft, R.M., and C. Ulibarri, Sexual differentiation of rat reproductive vs. opioid antinociceptive systems. Gender Med, 2009, 6: p. 209-224.
Craft, R.M., Sex differences in analgesic, reinforcing, discriminative, and motoric effects of opioids. Exp Clin Psychopharmacol, 2008. 16(5): p. 376-85.
Craft, R.M. and M.D. Leitl, Gonadal hormone modulation of the behavioral effects of Delta9-tetrahydrocannabinol in male and female rats. Eur J Pharmacol, 2008. 578(1): p. 37-42.
Craft, R.M., C. Ulibarri, M.D. Leitl, and J.E. Sumner, Dose- and time-dependent estradiol modulation of morphine antinociception in adult female rats. Eur J Pain, 2008. 12(4): p. 472-9.
Sell, S.L., R.M. Craft, P.K. Seitz, S.J. Stutz, K.A. Cunningham, and M.L. Thomas, Estradiol-sertraline synergy in ovariectomized rats. Psychoneuroendocrinology, 2008. 33(8): p. 1051-60.
Bernal, S.A., M.M. Morgan, and R.M. Craft, PAG mu opioid receptor activation underlies sex differences in morphine antinociception. Behav Brain Res, 2007. 177(1): p. 126-33.
Craft, R.M., Modulation of pain by estrogens. Pain, 2007. 132 Suppl 1: p. S3-12.
Craft, R.M., J.L. Clark, S.P. Hart, and M.K. Pinckney, Sex differences in locomotor effects of morphine in the rat. Pharmacol Biochem Behav, 2006. 85(4): p. 850-8.
Craft, R.M. and M.D. Leitl, Potentiation of
morphine antinociception by pentobarbital in female
vs. male rats. Pain, 2006. 121(1-2): p. 115-25.
Krivsky, J.A., E.C. Stoffel, J.E. Sumner, B.C. Inman, and R.M. Craft, Role of ventral tegmental area, periaqueductal gray and parabrachial nucleus in the discriminative stimulus effects of morphine in the rat. Behav Pharmacol, 2006. 17(3): p. 259-70.
Sumner, J.E., C. Ulibarri, and R.M. Craft, Testosterone modulation of reproductive indices vs. morphine antinociception in male rats. Life Sci, 2006. 79(22): p. 2119-27.
Craft, R.M., Sex differences in behavioral effects of cannabinoids. Life Sci, 2005. 77(20): p. 2471-8.
Craft, R.M. and D.A. Lee, NMDA antagonist modulation of morphine antinociception in female vs. male rats. Pharmacol Biochem Behav, 2005. 80(4): p. 639-49.
Stoffel, E.C., C.M. Ulibarri, J.E. Folk, K.C. Rice, and R.M. Craft, Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats. J Pain, 2005. 6(4): p. 261-74.