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Research Interests
Toxicology, Testis Biology, Aging, Prostate, Sertoli cell
Function
Research Summary
My research interest involves the study of male reproductive tract and fetal origins of adult disease. We use embryonic exposures to environmental toxins as a model to study how alterations in embryonic development lead to adult onset disease. We study how a class of environmental fungicides can affect adult spermatogenesis and prostate hyperplasia. We study several aspects of the adult male reproductive tract including aging, hormonal regulation and inheritance.
Research Publications
Selected 2005-2009
Bethel, C.R., J. Chaudhary, M.D. Anway, and
T.R. Brown, Gene expression changes are age-dependent and
lobe-specific in the Brown Norway rat model of prostatic
hyperplasia. Prostate, 2009. 69(8): p. 838-50.
Omwancha, J., M.D. Anway, and T.R. Brown,
Differential age-associated regulation ofclusterin expression in
prostate lobes of Brown Norway rats. Prostate, 2009. 69(2): p.
115-25.
Skinner, M.K., M.D. Anway, M.I. Savenkova, A.C.
Gore, and D. Crews, Transgenerational epigenetic programming of the
brain transcriptome and anxiety behavior. PLoS One, 2008. 3(11): p.
e3745.
Memon, M.A., M.D. Anway, T.R. Covert, M. Uzumcu,
and M.K. Skinner, Transforming growth factor beta (TGFbeta1,
TGFbeta2 and TGFbeta3) null-mutant phenotypes in embryonic gonadal
development. Mol Cell Endocrinol, 2008. 294(1-2): p. 70-80.
Clement, T.M., M.D. Anway, M. Uzumcu, and M.K.
Skinner, Regulation of the gonadal transcriptome during sex
determination and testis morphogenesis: comparative candidate
genes. Reproduction, 2007. 134(3): p. 455-72.
Skinner, M.K. and M.D. Anway, Epigenetic
transgenerational actions of vinclozolin on the development of
disease and cancer. Crit Rev Oncog, 2007. 13(1): p. 75-82
Anway, M.D., C. Leathers, and M.K. Skinner,
Endocrine disruptor vinclozolin inducedepigenetic transgenerational
adult-onset disease. Endocrinology, 2006. 147(12): p. 5515-23.
Anway, M.D., M.A. Memon, M. Uzumcu, and M.K.
Skinner, Transgenerational effect of the endocrine disruptor
vinclozolin on male spermatogenesis. J Androl, 2006. (6): p.
868-79..
Anway, M.D., A.S. Cupp, M. Uzumcu, and M.K.
Skinner, Epigenetic transgenerational actions of endocrine
disruptors and male fertility. Science, 2005. 308(5727): p.
1466-9.
Anway, M.D., M.D. Show, and B.R. Zirkin, Protein C
inhibitor expression by adult rat Sertoli cells: effects of
testosterone withdrawal and replacement. J Androl, 2005. 26(5): p.
578-85.
Skinner, M.K. and M.D. Anway, Seminiferous cord
formation and germ-cell programming:epigenetic transgenerational
actions of endocrine disruptors. Ann N Y Acad Sci, 2005. 1061: p.
18-32.