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Research Interests
Chromosome abnormalities in pregnancy; meiotic recombination
Research Summary
Over 50% of all human pregnancy loss is due to chromosome imbalance in the fetus, making chromosome abnormalities the leading cause of reproductive failure. One of the primary aims of my laboratory is the use of cytogenetic and molecular techniques to study the origin and etiology of human chromosome abnormalities, with the aim being to uncover basic mechanisms responsible for the errors. Additionally, because of the importance of abnormal meiotic recombination to the genesis of human trisomies, we have recently initiated a series of studies to examine factors responsible for “setting” recombination levels in mammalian males and females.
Research Publications
Selected 2005-2009
Hassold T. and Hunt P., Maternal age and chromosomlly abnormal pregnancies: what we know and what we wish we knew. Curr Opin Ped 2009 (in press).
Cheng E, Hunt P, Naluai-Cecchini T, Fligner C, Fujimoto V, Pasternack T, Schwartz J, Steinauer J, Woodruff T, Cherry S, Hansen T, Vallente R, Broman K, Hassold T. Meiotic recombination in human oocytes. PLoS Genetics 2009 (in press).
Hunt, P.A., M. Susiarjo, C. Rubio, and T.J. Hassold, The Bisphenol A Experience: A Primer for the Analysis of Environmental Effects on Mammalian Reproduction. Biol Reprod, 2009 (in press).
Hassold, T., T. Hansen, P. Hunt, and C. VandeVoort, Cytological studies of recombination in rhesus males. Cytogenet Genome Res, 2009. 124(2): p. 132-8.
Houmard, B., C. Small, L. Yang, T. Naluai-Cecchini, E. Cheng, T. Hassold, and M. Griswold, Global gene expression in the human fetal testis and ovary. Biol Reprod, 2009. 81(2): p. 438-43.
Myers, J.P., F.S. vom Saal, B.T. Akingbemi, K. Arizono, S. Belcher, T. Colborn, I. Chahoud, D.A. Crain, F. Farabollini, L.J. Guillette, Jr., T. Hassold, S.M. Ho, P.A. Hunt, T. Iguchi, S. Jobling, J. Kanno, H. Laufer, M. Marcus, J.A. McLachlan, A. Nadal, J. Oehlmann, N. Olea, P. Palanza, S. Parmigiani, B.S. Rubin, G. Schoenfelder, C. Sonnenschein, A.M. Soto, C.E. Talsness, J.A. Taylor, L.N. Vandenberg, J.G. Vandenbergh, S. Vogel, C.S. Watson, W.V. Welshons, and R.T. Zoeller, Why public health agencies cannot depend on good laboratory practices as a criterion for selecting data: the case of bisphenol A. Environ Health Perspect, 2009. 117(3): p. 309-15.
Muhlhauser, A., M. Susiarjo, C. Rubio, J. Griswold, G. Gorence, T. Hassold, and P.A. Hunt, Bisphenol A effects on the growing mouse oocyte are influenced by diet. Biol Reprod, 2009. 80(5): p. 1066-71.
Anderson, E.L., A.E. Baltus, H.L. Roepers-Gajadien, T.J. Hassold, D.G. de Rooij, A.M. van Pelt, and D.C. Page, Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice. Proc Natl Acad Sci U S A, 2008. 105(39): p. 14976-80.
Hunt, P.A. and T.J. Hassold, Human female meiosis: what makes a good egg go bad? Trends Genet, 2008. 24(2): p. 86-93.
Sanderson, M.L., T.J. Hassold, and D.T. Carrell, Proteins involved in meiotic recombination: a role in male infertility? Syst Biol Reprod Med, 2008. 54(2): p. 57-74.
Hall, H.E., E.R. Chan, A. Collins, L. Judis, S. Shirley, U. Surti, L. Hoffner, A.E. Cockwell, P.A. Jacobs, and T.J. Hassold, The origin of trisomy 13. Am J Med Genet A, 2007. 143A(19): p. 2242-8.
Hall, H.E., U. Surti, L. Hoffner, S. Shirley, E. Feingold, and T. Hassold, The origin of trisomy 22: evidence for acrocentric chromosome-specific patterns of nondisjunction. Am J Med Genet A, 2007. 143A(19): p. 2249-55.
Hassold, T., H. Hall, and P. Hunt, The origin of human aneuploidy: where we have been, where we are going. Hum Mol Genet, 2007. 16 Spec No. 2: p. R203-8.
Vallente, R.U., E.Y. Cheng, and T.J. Hassold, The synaptonemal complex and meiotic recombination in humans: new approaches to old questions. Chromosoma, 2006. 115(3): p. 241-9.
Hodges CA, Revenkova E, Jessberger R, Hassold
TJ, Hunt PA. 2005 SMC1beta-deficient female mice
provide evidence that cohesions are a missing link in age-related
nondisjunction. Nat Genet. 37(12):1351-5.