The genetic regulation of mammalian meiosis and the effects of allelic variation in genes involved in this process.
My research focuses on characterizing the relationship between genomics and the prevalence of disease or adverse physiological conditions. More specifically, and of relevance to reproductive biology, I am interested in the association of genotypes and allele specific expression with the incidence of meiotic errors. Towards this goal, I examine phenotypic perturbations in gametogenesis, in accordance with genetic markers. These complex traits are not solely attributable to the altered genetic sequences of single candidate genes, as a result I am currently investigating a number of candidate genes in chromosomal regions that are associated with higher and lower frequencies of meiotic recombination. It is well established that abnormal recombination frequencies and placement contributes to the occurrence of non-disjunction. My hope is that this strategy will provide a greater understanding of genetic influences in various stages of mammalian meiosis including but not limited to homologous recombination and cohesin complexes.
Murdoch BM, Murdoch GK, Greenwood S, McKay S. Nutritional influence on epigenetic marks and effects on livestock production. Frontiers in Genetics, (2016) Oct 24;7: 182.
Murdoch B, Owen N, Stevense M, Smith H, Nagaoka S, Hassold T, McKay M, Xu H, Fu J, Revenkova E, Jessberger R, Hunt P. Altered cohesin gene dosage affects mammalian meiotic chromosome structure and behavior. PLoS Genet (2013) 9(2) e1003241.
Hunt PA, Lawson C, Gieske M, Murdoch B, Smith H, Marre A, Hassold T, VandeVoort CA. Bisphenol A alters early oogenesis and follicle formation in the fetal ovary of the rhesus monkey. Proc Natl Acad Sci (2012) Oct 23: 109 (43): 17525-30.
Murdoch BM, Murdoch GK, Settles M, McKay S, Williams JL, Moore SS. Genome-wide scan identifies loci associated with classical BSE occurrence. PLoS One (2011) 6(11) e26819.
Lawson C, Giekse M, Murdoch B, Ye P, Li Y, Hassold T, Hunt PA. Gene expression in the fetal mouse ovary is altered by exposure to low doses of bisphenol A. Biol Reprod. (2011) Jan 84 (1): 79-86.
Murdoch B, Owen N, Shirley S, Crumb S, Broman KW, Hassold T. Multiple loci contribute to genome-wide recombination levels in male mice. Mamm Genome (2010) Dec 21 (11-12): 550-555.
Gorbach DM, Makgahlela ML, Reecy JM, Kemp SJ, Balyenweck I, Ouma R, Mwai O, Marshall K, Murdoch B, Moore S, Rothschild MF. Use of SNP genotyping to determine pedigree and breed composition of dairy cattle in Kenya. J Anim Breed Genet. (2010) Oct 127 (5): 348-351.
Murdoch BM, Clawson ML, Yue S, Basu U, McKay S, Settles M, Capoferri R, Laegreid WW, Williams JL, Moore SS. PRNP haplotype associated with classical BSE incidence in European Holstein cattle. PLoS One (2010) Sept 16: 5(9) e12786.
Murdoch BM, Clawson ML, Laegreid WW, Stothard P, Settles M, McKay S, Prasad A, Wang Z, Moore SS, Williams JL. A 2cM genome-wide scan of European Holstein cattle affected by classical BSE. BMC Genet. (2010) Mar 29 11:20.
Bovine HapMap Consortium. Genome-wide survey of SNP variation uncovers the genetic structure of cattle breeds. Science (2009) Apr 24 324(5926):528-532.