Participating Faculty

Holly-Neibergs-lg

Holly Neibergs

Department:Animal Sciences, WSU
Credentials:1993-Ph.D., Texas A&M University-Philosophy, Genetics
Office:ASLB 210
Phone:509-335-6491
Fax:509-335-1082
Mailing Address:Animal Science
Washington State University
PO Box 646353
Pullman, WA 99164-6353
E-mail:neibergs@wsu.edu
Website:Click here


Research Interests

Comparative and functional genomics, genetic susceptibility to disease, genetics of reproduction.

Research Summary

Current projects involve the investigation of genetic susceptibility and tolerance to bovine paratuberculosis and bovine respiratory disease, and the genetic role of fertility in dairy and beef cattle.

Research Publications

J.G.N. Moraes, S.K. Behura, T.W. Geary, P.J. Hansen, T.R. Hansen, H.L. Neibergs, T.E. Spencer. 2018. Uterine influences on conceptus development in fertility-classified heifers. Proceedings National Academy of Science USA. 10.1073/pnas.1721191115  

S.K. Behura, P.C. Tizioto, J. Woo Kim, N.V. Grupioni, C.M. Seabury, R.D. Schnabel, L.J. Gershwin, A.L. Van Eenennaam, R. Toaff-Rosenstein, H.L. Neibergs, L.C. Regitano, the Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team, J.F. Taylor. 2017. Tissue tropism in host transcriptional response to members of the bovine respiratory disease complex. Scientific Reports. 7:17938 doi:10.1038/s41598-017-18205-0 

M. Neupane, T.W. Geary, J.N. Kiser, G.W. Burns, T.E. Spencer, H.L. Neibergs. Loci and pathways associated with uterine capacity for pregnancy and fertility in beef cattle. PLoSOne. 12(12): e0188997.doi: 10.1271/journal.pone.0188997 

J.N. Kiser, M. Neupane, S.N. White, H.L. Neibergs. Identification of genes associated with susceptibility to Mycobacterium avium ssp. paratuberculosis (Map) tissue infection in Holstein cattle using gene set enrichment analysis – SNP. Mammalian Genome. https://doi.org/10.1007/s00335-017-9725-4

C.M. Seabury, D.L. Oldeschulte M. Saatchi, J.E. Beever, J.E. Decker, Y.A. Halley, E.K. Bhattarai, M. Molaei, H.C. Freetly, S.L. Hansen, H. Yampara-Iquise, K.A. Johnson, M.S. Kerley, J. Woo Kim, D.D. Loy, E. Marques, H.L. Neibergs, R.D. Schnabel, D.W. Shike, M.L. Spangler, R.L. Weaber, D.J. Garrick, J.F. Taylor. 2017. Genome-wide association study for feed efficiency and growth traits in U.S. beef cattle. BMC Genomics. 18:386. DOI: 10.1186/s12864-017-3754-y

J.N. Kiser, T.E. Lawrence, M. Neupane, C.M. Seabury, J.F. Taylor, J. E. Womack, the Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team, H.L. Neibergs. 2017. Rapid Communications: Subclinical bovine respiratory disease – loci and pathogens associated with lung lesions in feedlot cattle. Journal Animal Science. 95(3):1080-1091. DOI:10.2527/jas.2016.1152 

M. Neupane, K.D. Moss, F. Avila, T. Raudsepp, B.M. Marron, J.E. Beever, S. Parish, J.N. Kiser, B. Cantrell, H.L. Neibergs. Case study: Polymelia in a Holstein calf. Professional Animal Scientist. 33(3):378-386. DOI:10.15232/pas.2016-01594 

J.N. Kiser, S.N. White, K.A. Johnson, J.L. Hoff, J.F. Taylor, H.L. Neibergs. 2017. Identification of loci associated with susceptibility to Mycobacterium avium subspecies paratuberculosis (Map) tissue infection in cattle. Journal of Animal Science. 95(3):1080-1091. DOI:10.2527/jas.2016.1152 

T.W. Geary, G.W. Burns, J.G.N. Moraes, J.I. Moss, A.C. Denicol, K.B. Dobbs, S. Ortega, P.J. Hansen, M.E. Wehrman, H. Neibergs, E. O’Neil, S. Behura, T.E. Spencer. 2016. Identification of beef heifers with superior uterine capacity for pregnancy. Biology of Reproduction 95(2):47. DOI:10.1095/biolreprod.116.141390 

J. Dalton, D. Moore, T.E. Spencer, P.J. Hansen, J.B. Cole, and H. Neibergs. 2016. Genetics, genomics, and fertility. Clinical Theriogenology. 8(3):165-170.

L.J. Gershwin, A.L. Van Eenennaam, M.L. Anderson, H. McEligot, M. Shao, S. Yarnes, R. Toeff-Rosenstein, J.F. Taylor, H.L. Neibergs, and Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team. 2015. Single pathogen challenge with agents of the bovine respiratory disease complex. PLosOne. 10(11):e0142479. DOI:10.1371/journal.pone.0142479 

P.C. Tizioto, J.W. Kim, C.M. Seabury, R.D. Schnabel, L.J. Gershwin, A.L. Van Eenennaam, R. Toaff-Rosenstein, H.L. Neibergs, the Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team, J.F. Taylor. 2015. Immunological response to single pathogen challenge with agents of the bovine respiratory disease complex: An RNA-sequence analysis of the bronchial lymph node transcriptome. PlosOne. 10(6):e0131459. DOI:10.1371/journal.pone.0131459 

T.F. Ng, N. Kondov, X. Deng, A. Van Eenennaam, H.L. Neibergs, E. Delwart. 2015. A metagenomics and case-control study to identify viruses associated with bovine respiratory disease. Journal Virology. 89(10):5340-5349.  DOI:10.1128/JVI.00064-15 

H.L. Neibergs, C.M. Seabury, A.J. Wojtowicz, Z. Wang, E. Scraggs, J. Kiser, M. Neupane, J.E. Womack, A. E. Van Eenennaam, G.R. Hagevoort, T.W. Lehenbauer, S. Aly, J. Davis, J.F. Taylor. 2014. Susceptibility loci revealed for bovine respiratory disease complex in pre-weaned Holstein calves. BMC Genomics. 15:1164. 

Van Eenennaam, H.L. Neibergs, C. Seabury, J. Taylor, Z. Wang, E. Scraggs,  R.D. Schnabel, J. Decker, A. Wojtowicz, S. Aly, J. Davis, P. Blanchard, B. Crossley, P. Rossitto, T. Lehenbauer, R. Hagevoort, E. Chavez, J.S. Neibergs, J.E. Womack. 2014.  Results of the BRD CAP project: progress toward identifying genetic markers associated with BRD susceptibility. Animal Health Research Reviews. 15(2):157-160. DOI:http://dx.doi.org/10.1017/S1466252314000231 

M. Saatchi, J.E. Beever, J.E. Decker, H.C. Freetly, S.L. Hansen, H. Yampara-Iquise, K.A. Johnson, M.S. Kerley, J.W. Kim, D.D. Loy, E. Marques, H.L. Neibergs, E.J. Pollak, R.D. Schnabel, C.M. Seabury, D.W. Shike, M.L. Spangler, R.L. Weaber, D.J. Garrick, J.F. Taylor. 2014. QTL, candidate genes, metabolic and signaling pathways associated with growth, metabolic mid-test weight, feed intake and fee efficiency in beef cattle. BMC Genomics. 15:1004. DOI:10.1186/1471-2164-15-1004 

E. Scraggs, A. Wojtwicz, R. Zanella, J.F. Taylor, C.T. Gaskins, J.J. Reeves, J.M. de Avila, H.L. Neibergs. 2013. Estimation of inbreeding and effective population size of full blood Wagyu cattle registered with the American Wagyu cattle association. Journal Animal Breeding and Genetics. 131(1):3-10. DOI:10.1111.jbg.12066 

M.A. Minten, T.R. Bilby, R.G.S. Bruno, C.C. Allen, C.A. Madsen, Z. Wang, J.E. Sawyer, A. Tibary, H.L. Neibergs, T.W. Geary, S. Bauersachs, T.E. Spencer. 2013. Effects of fertility on gene expression and function of the bovine endometrium. PLoSOne. 8(8):e69444. DOI:10.1371/journal.pone.0069444 

White, S.N., M.R. Mousel, et al. 2012. Genome-Wide association identifies multiple genomic regions associated with susceptibility to and severity of ovine lentivirus. PLoS One. 7(10): e47829. doi:10.1371/journal.pone.0047829

Wilson, K., R. Zanella, et al. 2012. Identification of chromosomal locations associated with tail biting and being a victim of tail biting behavior in the domestic pig (Sus scrofa domesticus). Journal of Applied Genetics. DOI: 10.1007/s13353-012-0112.

Minozzi, G., J.L. Williams, et al. 2012. Meta-analysis of two genome wide association studies of bovine paratuberculosis. PLoS One 7(3):e32578. Epub 2012 Mar 2. 

Garrick, D., L. Baumgard, H.L. Neibergs. 2012. Genomic analysis of data from physiological studies. Journal of Dairy Science. 95:499-507. 

Zanella, R., E.G. Casas, et al. 2011. Fine mapping of loci on BTA2 and BTA26 associated with bovine viral diarrhea persistent infection and linked with bovine respiratory disease in cattle. Frontiers in Livestock Genomics. 2:82. doi: 10.3389/fgene.2011.00082 

Zanella, R., R.H Whitlock, H.L. Neibergs. 2011. Short communication: Fine mapping of genetic regions associated with Mycobacterium avium subspecies paratuberculosis tissue infection and tolerance to Johne’s disease. Journal of Dairy Science 94:4230-4236. 

Zanella, R., M. L. Settles, et al. (2011). Identification of loci associated with tolerance to Johne's disease in Holstein cattle. Animal genetics 42(1): 28-38.

Neibergs, H., R. Zanella, et al. (2011). Loci on Bos taurus chromosome 2 and Bos taurus chromosome 26 are linked with bovine respiratory disease and associated with persistent infection of bovine viral diarrhea virus. Journal of Animal Science 89(4): 907-915.

Neibergs, H. L., M. L. Settles, et al. (2010). "GSEA-SNP identifies genes associated with Johne's disease in cattle." Mamm Genome 21(7-8): 419-425.

Decker, J.E., J.C. Pires, G.C. Conant, S.D. McKay, M.P. Heaton, J. Vilkki, C.M. Seabury, A.R. Caetano, G.S. Johnson, R.A. Brenneman, O. Hanotte, L.S. Eggert, P. Wiener, J.-J. Kim, K.S. Kim, T.S. Sonstegard, C. Van Tassell, H.L. Neibergs, K. Chen, A. Coooper, J. McEwan, R. Brauning, M.C. McClure, M.M. Rolf, J.W. Kim, R.D. Schnabel, J.F. Taylor. High-throughput phylogenomics: From ancient DNA to signatures of human animal husbandry. Proceedings National Academy Science, USA.  44:18644-18649.

Settles, M., R. Zanella, S.D. McKay, R.D. Schnabel, J.F. Taylor, R. Whitlock, Y. Schukken, J.S. Van Kessel, J.M. Smith, and H. Neibergs, A whole genome association analysis identifies loci associated with Mycobacterium avium subsp. paratuberculosis infection status in US Holstein cattle. Anim Genet, 2009. 40:655-662.

Heaton, M.P., J.W. Keele, G.P. Harhay, J.A. Richt, M. Koohmaraie, T.L. Wheeler, S.D. Shackelford, E. Casas, D.A. King, T.S. Sonstegard, C.P. Van Tassell, H.L. Neibergs, C.C. Chase, Jr., T.S. Kalbfleisch, T.P. Smith, M.L. Clawson, and W.W. Laegreid, Prevalence of the prion protein gene E211K variant in U.S. cattle. BMC Vet Res, 2008. 4: p. 25.

Washington State University