Participating Faculty

CRB Faculty

Administrators


James Pru

James Pru

Associate Director, CRB
Animal Sciences & Associate Faculty in SMB; WSU

jpru@wsu.edu
Office
Room: VMRB171
Phone: 509-335-8913

 

Understanding the molecular dialog of early pregnancy, mechanisms of endometrial regeneration, PGRMC1 and PGRMC2 actions in female reproduction and women’s reproductive diseases
My research focuses on understanding molecular events coordinating the physiology of embryo implantation using the mouse and domestic ruminants as model organisms. With a basic understanding of these processes, the long-term goal is to identify mechanisms that, when gone awry, contribute to infertility during early gestation. Related to embryo implantation, we are specifically interested in the processes by which the embryo signals its presence as it invades the uterine wall in an effort to establish an exchange apparatus for nutrients and waste. As progesterone coordinates many of the uterine events during embryo implantation, we are also interested in how ovarian-derived progesterone signals in the endometrium by non-classical mechanisms. We recently demonstrated expression of a novel membrane progestin receptor in the uterus and ongoing studies are designed to test the functional importance of this putative receptor in uterine physiology and pathophysiology. In related studies, efforts are being made to learn how resident stem/progenitor cells of the endometrium contribute to uterine repair during the estrous/menstrual cycle and following parturition.
Select Publications
  • Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK (2017) Conditional ablation of progesterone receptor membrane component 2 causes female premature reproductive senescence.  Endocrinology 158(3):640-651. doi: 10.1210/en.2016-1701 PMID: 28005395 PMCID: PMC5460782
  • Clark NC, Pru CA, Pru JK (2017) Novel Regulators of Hemodynamics in the Pregnant Uterus. Prog Mol Biol Transl Sci 145:181-216. doi: 10.1016/bs.pmbts.2016.12.007. Epub 2017 Jan 12. PMID: 28110751 PMCID:
  • McCallum ML, Pru CA, Niikura Y, Yee SP, Lydon JP, Peluso JJ, Pru JK (2016) Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts. Endocrinology 157(9):3309-19. doi: 10.1210/en.2016-1081. Epub 2016 Jun 16. PMID: 27309940 PMCID: PMC5007897
  • Clark NC, Friel AM, Pru CA, Zhang L, Shioda T, Rueda BR, Peluso JJ, Pru JK (2016) Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors. Cancer Biol Ther 17(3):262-71. doi: 10.1080/15384047.2016.1139240. Epub 2016 Jan 19. PMID: 26785864 PMCID: PMC4847980
  • Dey S, Chamero P, Pru JK, Chien MS, Ibarra-Soria X, Spencer KR, Logan DW, Matsunami H, Peluso JJ, Stowers L (2015) Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior. Cell 161(6):1334-44. doi: 10.1016/j.cell.2015.04.052 PMID: 26046438 PMCID: PMC4501503
  • Henkes LE, Pru JK, Ashley RL, Anthony RV, Veeramachaneni DN, Gates KC, Hansen TR (2015) Embryo mortality in Isg15-/- mice is exacerbated by environmental stress. Biol Reprod 92(2):36. doi: 10.1095/biolreprod.114.122002. Epub 2014 Dec 10. PMID: 25505199 PMCID:
  • Friel AM, Zhang L, Pru CA, Clark NC, McCallum ML, Blok LJ, Shioda T, Peluso JJ, Rueda BR, Pru JK. (2015) Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors. Cancer Lett 356(2 Pt B):434-42. doi: 10.1016/j.canlet.2014.09.036. Epub 2014 Oct 7. PMID: 25304370 PMCID: PMC4259802

General Membership


James Pru

James Pru

Associate Director, CRB
Animal Sciences & Associate Faculty in SMB; WSU

jpru@wsu.edu
Office
Room: VMRB171
Phone: 509-335-8913

 

Understanding the molecular dialog of early pregnancy, mechanisms of endometrial regeneration, PGRMC1 and PGRMC2 actions in female reproduction and women’s reproductive diseases
My research focuses on understanding molecular events coordinating the physiology of embryo implantation using the mouse and domestic ruminants as model organisms. With a basic understanding of these processes, the long-term goal is to identify mechanisms that, when gone awry, contribute to infertility during early gestation. Related to embryo implantation, we are specifically interested in the processes by which the embryo signals its presence as it invades the uterine wall in an effort to establish an exchange apparatus for nutrients and waste. As progesterone coordinates many of the uterine events during embryo implantation, we are also interested in how ovarian-derived progesterone signals in the endometrium by non-classical mechanisms. We recently demonstrated expression of a novel membrane progestin receptor in the uterus and ongoing studies are designed to test the functional importance of this putative receptor in uterine physiology and pathophysiology. In related studies, efforts are being made to learn how resident stem/progenitor cells of the endometrium contribute to uterine repair during the estrous/menstrual cycle and following parturition.
Select Publications
  • Clark NC, Pru CA, Yee SP, Lydon JP, Peluso JJ, Pru JK (2017) Conditional ablation of progesterone receptor membrane component 2 causes female premature reproductive senescence.  Endocrinology 158(3):640-651. doi: 10.1210/en.2016-1701 PMID: 28005395 PMCID: PMC5460782
  • Clark NC, Pru CA, Pru JK (2017) Novel Regulators of Hemodynamics in the Pregnant Uterus. Prog Mol Biol Transl Sci 145:181-216. doi: 10.1016/bs.pmbts.2016.12.007. Epub 2017 Jan 12. PMID: 28110751 PMCID:
  • McCallum ML, Pru CA, Niikura Y, Yee SP, Lydon JP, Peluso JJ, Pru JK (2016) Conditional Ablation of Progesterone Receptor Membrane Component 1 Results in Subfertility in the Female and Development of Endometrial Cysts. Endocrinology 157(9):3309-19. doi: 10.1210/en.2016-1081. Epub 2016 Jun 16. PMID: 27309940 PMCID: PMC5007897
  • Clark NC, Friel AM, Pru CA, Zhang L, Shioda T, Rueda BR, Peluso JJ, Pru JK (2016) Progesterone receptor membrane component 1 promotes survival of human breast cancer cells and the growth of xenograft tumors. Cancer Biol Ther 17(3):262-71. doi: 10.1080/15384047.2016.1139240. Epub 2016 Jan 19. PMID: 26785864 PMCID: PMC4847980
  • Dey S, Chamero P, Pru JK, Chien MS, Ibarra-Soria X, Spencer KR, Logan DW, Matsunami H, Peluso JJ, Stowers L (2015) Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior. Cell 161(6):1334-44. doi: 10.1016/j.cell.2015.04.052 PMID: 26046438 PMCID: PMC4501503
  • Henkes LE, Pru JK, Ashley RL, Anthony RV, Veeramachaneni DN, Gates KC, Hansen TR (2015) Embryo mortality in Isg15-/- mice is exacerbated by environmental stress. Biol Reprod 92(2):36. doi: 10.1095/biolreprod.114.122002. Epub 2014 Dec 10. PMID: 25505199 PMCID:
  • Friel AM, Zhang L, Pru CA, Clark NC, McCallum ML, Blok LJ, Shioda T, Peluso JJ, Rueda BR, Pru JK. (2015) Progesterone receptor membrane component 1 deficiency attenuates growth while promoting chemosensitivity of human endometrial xenograft tumors. Cancer Lett 356(2 Pt B):434-42. doi: 10.1016/j.canlet.2014.09.036. Epub 2014 Oct 7. PMID: 25304370 PMCID: PMC4259802